OmniBol is a topical formulation that contains DHEA (Dehydroepiandrosterone) and pregnenolone. These compounds are precursors to various hormones, including androgens, glucocorticoids, mineralocorticoids, and sex steroids. Topical administration of OmniBol has been suggested to increase both the half-life and effectiveness of DHEA, favoring its conversion via androgenic pathways, thereby potentially minimizing estrogenic side effects often associated with oral DHEA consumption.
Ray Peat calls DHEA and Pregnenolone the "steroids of youth", mentioning their importance in mitigating stress (decreasing cortisol), optimizing cognition, strengthening skin, bones and other organs, and healthy aging.
OmniBol is our formulation of steroidogenesis enhancers (Enhancers of the creation of natural masculine steroids/hormones), Omni meaning “All” and Bol being short for the suffix -bolic, referring to anabolic, signifying OmniBol's capability to boost masculinising androgens and do so in a manner that is holistic, synergistic, and all-encompassing; all while being sustainable and not suppressing or stopping natural androgen production.
This post serves as a collection of relevant information on OmniBol in a clean, concise format.
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Why administer DHEA and Pregnenolone topically rather than orally?
Topical administration of steroids like DHEA and pregnenolone offers several advantages over oral consumption:
- Increased Half-life and Effectiveness: Topical application can enhance the half-life and effectiveness of these steroids, allowing for sustained and effective levels in the bloodstream.
- Favors Androgenic Pathways: Topical use of DHEA has been shown to promote its conversion through androgenic pathways, which may reduce concerns about potential estrogenic side effects often linked with oral DHEA intake.
- Minimized Estrogenic Side Effects: A single dose of topical OmniBol might provide the benefits of 100mg+ oral DHEA without the associated estrogenic side effects.
- Better Hormonal Profiles: Studies have suggested that while there might not be significant differences in circulating levels of DHEA, testosterone, or estrogen between different topical forms, topical administration in general seems to favor androgen metabolism more than oral administration. This means topical applications could lead to increased levels of androgens like testosterone compared to oral consumption.
- Sustained Release: Topical DHEA has shown prolonged blood values of hormones over several days, indicating a longer-lasting effect compared to oral ingestion.
Overall, topical administration appears to offer a more controlled and favorable hormonal response than oral consumption, with reduced potential side effects.
What is the optimal OmniBol dose?
The optimal dose of OmniBol, when applied topically, lies between 3-15mg of DHEA and 3-15mg of Pregnenolone, which is equivalent to 1-5 sprays.
However, it is imperative not to exceed a total daily DHEA dose of 15mg when using topically. Studies have shown that estrogen levels rise when the daily DHEA dosage surpasses 18mg, particularly with a 0.3% DHEA cream.
Therefore, to maintain hormonal balance and avoid potential side effects, staying within the recommended range is crucial.
Benefits of Pregnenolone:
- Acts as a precursor for various steroids, including glucocorticoids, mineralocorticoids, and sex steroids.
- Has potential neuroprotective properties, safeguarding the brain against injury and degenerative diseases.
- Supports cognitive functions, potentially enhancing memory and learning capabilities.
- May help in the management of arthritis-related pain and decrease inflammation.
- Plays a role in mood regulation, potentially alleviating symptoms of depression and mood disorders.
- Supports the production of other essential hormones, aiding in hormonal balance.
- Can potentially combat fatigue and increase energy levels.
- May aid in stress management by balancing cortisol levels.
Benefits of DHEA:
- Contributes to enhanced muscle strength and lean body mass.
- Boosts levels of other androgens like testosterone, promoting anabolic activity.
- Has potential anabolic effects, stimulating DNA synthesis in muscle and organs, potentially aiding tissue repair and growth.
- Supports bone density, potentially reducing the risk of osteoporosis.
- Contributes to improved skin health, possibly due to its role in collagen production.
- May have a role in improving cardiovascular health and decreasing the risk of heart disease.
- Supports immune system function, possibly reducing susceptibility to infections.
- Can help in managing systemic lupus erythematosus (SLE) symptoms.
- Contributes to general hormonal balance, aiding in mood stabilization and stress response.
- May play a role in enhancing libido and sexual function.
More information and references may be found on Examine's breakdown of DHEA, and on LifeExtensions breakdown of Pregnenolone.
OmniBol - DHEA and Pregnenolone Spray
