Vitamin D3 K2 Spray is a topical formulation that contains Vitamin D3 and the MK-4 form of Vitamin K2. These compounds upregulate and enhance steroidogenesis, contributing to the production of androgens such as Testosterone. Topical administration of D3 and K2 has been shown to increase testosterone production, with current research highlighting their significant roles in male reproductive health. Specifically, studies have pointed out that Vitamin D3 has a direct influence on male testicular androgenesis, enhancing the production of testosterone at the cellular level. Meanwhile, Vitamin K2 MK-4 stimulates testosterone production mechanisms, particularly through PKA activation in Leydig cells.
The roles of Vitamin D3 and Vitamin K2 MK-4, especially in male health, have gained attention in recent research. Let's delve into the key findings regarding their topical application and effects on androgenesis.
Vitamin D3, often associated with bone health and sunlight exposure, has shown potential benefits in the realm of male reproductive health. A pilot study on the topical delivery of Vitamin D3 indicated that when applied to the skin, Vitamin D3 can either function locally or enter the systemic circulation. The study found topical application of Vitamin D3 to be both effective and safe.
Additionally, research titled "Testicular Synthesis and Vitamin D Action" identified Vitamin D's role in male steroidogenesis in vitro. The study found that a specific form of Vitamin D3, 1,25(OH)2D3, increases testosterone production in human testicular cells.
Vitamin K2 MK-4's impact on testosterone production has been highlighted in recent studies. Research showed that MK-4 stimulates testosterone production in rats and testis-derived tumor cells through PKA activation in Leydig cells. This activation leads to an increase in the expression of the enzyme CYP11A1, promoting the conversion of cholesterol to pregnenolone and increasing testosterone production.
Furthermore, MK-4 has been observed to linearly enhance the expression of CYP11A mRNA in the testis with increased concentration, suggesting a dose-dependent relationship.
The combined benefits of Vitamin D3 and Vitamin K2 MK-4, particularly in a topical spray form, offer promising avenues for further research. Their potential roles in enhancing male reproductive health and androgenesis underscore the importance of continued studies in this field.
A direct enhancing effect on leydig cells was found with Vitamin D3 and Vitamin K2 MK-4, which can be achieved with topical application locally to enhance androgenesis.
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Topical Delivery of Vitamin D3: A Randomized Controlled Pilot Study
"Application of topical products to the skin can act locally or pass into the systemic circulation, or do both." .. "In conclusion the results of our study dictate us to state that topical route of vitamin D is possible, efficacious and safe."
Testicular Synthesis and Vitamin D Action
"Data from our human primary testicular cell culture model suggest that vitamin D plays a major role in male steroidogenesis in vitro." .. "Our results provide evidence that 1,25(OH)2D3 [Vitamin D3] is directly involved in human male testicular androgenesis. In primary human testicular cells, we show that 1,25(OH)2D3 [Vitamin D3] increases T production and mRNA expression of enzymes involved in androgen production and their precursors. We are the first to show the up-regulation of steroidogenic gene expression in healthy human testicular cells"
Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells
"MK-4 [Vitamin K2 MK-4] stimulates testosterone production in rats and testis-derived tumor cells via activation of PKA. MK-4 [Vitamin K2 MK-4] may be involved in steroidogenesis in the testis." .. "We found that MK-4 [Vitamin K2 MK-4] stimulates testosterone production in rats and testis-derived tumor cells."
MK-4 [Vitamin K2 MK-4] stimulates PKA activation in Leydig cells, which in turn enhances the expression of CYP11A1, leading to the conversion of cholesterol into pregnenolone and ultimately resulting in increased testosterone production/androgenesis.
MK-4 contributes to the maintenance of the normal testosterone production in the rat testis
The relative expression of CYP11A mRNA in the testis is enhanced by MK-4 [Vitamin K2 MK-4] concentration in a linear, dose-dependent manner.
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Vitamin D3 K2 Spray
